Biochemical indicators of nephrotoxicity in blood serum of rats treated with novel 4-thiazolidinone derivatives or their complexes with polyethylene glycol-containing nanoscale polymeric carrier [Text] = Біохімічні показники нефротоксичності у сироватці крові щурів за дії нових похідних 4-тіазолідинонів та їхніх комплексів із поліетиленглікольвмісним полімерним нанорозмірним носієм / L. I. Kоbylinska [et al.] // Український біохімічний журнал. - 2016. - Т. 88, № 1. - P51-60. - Бібліогр.: в кінці ст.
MeSH-главная:
МОДЕЛИ НА ЖИВОТНЫХ -- MODELS, ANIMAL
КРОВИ СЫВОРОТКА -- SERUM (метаболизм, химия)
ПОЧЕЧНАЯ ЭЛИМИНАЦИЯ -- RENAL ELIMINATION (физиология)
ТИАЗОЛИДИНЫ -- THIAZOLIDINES (анализ, метаболизм, химический синтез)
ДОКСОРУБИЦИН -- DOXORUBICIN (анализ, кровь, метаболизм)
ЛЕКАРСТВ ОЦЕНКА ДОКЛИНИЧЕСКАЯ -- DRUG EVALUATION, PRECLINICAL (методы, статистика, тенденции)
ПОЛИЭТИЛЕНГЛИКОЛИ -- POLYETHYLENE GLYCOLS (анализ, химический синтез)
НАНОТЕХНОЛОГИЯ -- NANOTECHNOLOGY (методы, тенденции)
Аннотация: The aim of this study was to compare the effect of new synthetic 4-thiazolidinone derivatives (potential anticancer compounds denoted as 3882, 3288 and 3833) and doxorubicin (positive control) in free form and in their complexes with synthetic polyethylene glycol-containing nanoscale polymeric carrier on the biochemical indicators of nephrotoxicity in blood serum of rats. The concentration of total protein, urea, creatinine, glucose, ions ofsodium, potassium, calcium, iron and chloride was measured. It was found that after injection of the investigated compounds, the concentration of sodium cations and chloride anions in blood serum was increased compared with control (untreated animals). Doxorubicin’s injection was accompanied by a decrease in the concentration of iron cations. The concentration of total protein, urea and creatinine decreased under the influence of the studied compounds. Complexation of these antineoplastic substances with a synthetic polymeric nanocarrier lowered the concentration of the investigated metabolites substantially compared to the effect of these compounds in free form. The normalization of concentration of total protein, urea and creatinine in blood serum of rats treated with complexes of the studied compounds with the polymeric carrier comparing with increased concentration of these indicators at the introduction of such compounds in free form was found.
Доп.точки доступа:
Kоbylinska, L. I.; Havrylyuk, D. Ya.; Mitina, N. E.; Zаichenko, A. S.; Lesyk, R. B.; Zіmenkovsky, B. S.; Stoika, R. S.
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