Research of the antimicrobial and antifungal activity of 7-((3-thio-4-R-4H-1,2,4-triazoles-3-yl) methyl)theophylline S-derivatives [] / A. S. Gotsulya [et al.] // Запорож. мед. журн. - 2015. - N 4. - С. 95-99 MeSH-главная: ТРИАЗОЛЫ -- TRIAZOLES (фармакология) ТЕОФИЛЛИН -- THEOPHYLLINE (фармакология) СТАФИЛОКОКК ЗОЛОТИСТЫЙ -- STAPHYLOCOCCUS AUREUS (действие лекарственных препаратов) ESCHERICHIA COLI -- ESCHERICHIA COLI (действие лекарственных препаратов) Аннотация: Aim. The research of antimicrobial and antifungal activity of 7-((3-thio-4-R-4H-1,2,4-triazoles-3-yl)methyl)theophylline S-derivatives has been erformed.Methods and results. Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, Pseudomоnas aeruginosa ATCC 27853, Candida albicans ATCC 885-653 have been taken as a set of standard test-strains. It has been proved that the most active alkyl-derivatives are 7-((3-thio- 4-R-4H-1,2,4-triazole-3-yl)methyl)theophylline. Among the synthesized salts, which turned to be active against Staphylococcus aureus, the 2-(5-((theophylline-7-yl)methyl)-4-phenyl-4H-1,2,4-triazole-3-ylthio)acetate ammonium has attracted our attention.Conclusion. The perspective class of compounds for further research on this type of biological activity has been defined. Доп.точки доступа: Gotsulya, A. S.; Kamyshnyi, O. M.; Polishchuk, N. M.; Panasenko, O. I.; Knysh, Ye. G. Экз-ры: