Kuznietsov, A. A.     Development of multivariate models for the verification of short-term vital and functional prognosis in patients with hemorrhagic hemispheric stroke in the onset of the disease / A. A. Kuznietsov // Патологія. - 2018. - N 1. - P88-94 MeSH-главная: ВНУТРИЧЕРЕПНЫЕ КРОВОИЗЛИЯНИЯ -- INTRACRANIAL HEMORRHAGES (диагностика, лекарственная терапия, осложнения, этиология) ТОМОГРАФИЯ РЕНТГЕНОВСКАЯ КОМПЬЮТЕРНАЯ -- TOMOGRAPHY, X-RAY COMPUTED (использование) СМЕРТНОСТЬ -- MORTALITY Аннотация: The main purpose of the study was to develop multivariate models for the verification of short-term vital and functional prognosis in patients with hemorrhagic hemispheric stroke in the onset of the disease. Materials and methods. A prospective, cohort, comparative study was conducted in 203 patients with spontaneous supra¬tentorial intracerebral hemorrhage (SSICH) (121 men and 82 women, mean age 65.1 ± 0.8 years), who were hospitalized within the first 12 hours since the onset of the disease and received conservative therapy. National Institute of Health Stroke Scale (NIHSS) score, Glasgow Coma Scale score, Full Outline of UnResponsiveness Scale score, intracerebral hemorrhage volume, displacement of the septum pellucidum and pineal gland, white blood cell count (WBCC), neutrophil count, lymphocyte count, monocyte count, neutrophil-to-lymphocyte ratio (NLR) were detected upon admission to the hospital. The functional outcome (FO) of the acute period of the disease was assessed on the 21st day in accordance with the modified Rankin Scale (mRS), whereas 3 points on this scale were considered as an unfavourable FO, ?3 points were considered as a favourable FO. Binary logistic regression method and ROC-analysis were used for the elaboration of prediction criteria. Results of research. Lethal outcome (12.3 %), unfavourable FO (37.5 %) and favourable FO (51.2 %) were registered in the structure of acute period outcomes of the disease. In accordance with the data of multivariate regression analysis it was determined that admission NIHSS score 16 (Se = 68.0 %, Sp = 93.3 %), septum pellucidum displacement 3 mm (Se = 84.0 %, Sp = 74.2 %) and admission WBCC 8 600 cells/?L (Se = 84.0 %, Sp = 62.4 %) are independently associated with an increased risk of the lethal outcome of the acute period of SSICH by 12.8 (12.8–26.8) (P 0.0001), 10.7 (3.8–29.8) (P 0.0001) and 6.9 (2.4–19.3) (P 9 (Se = 90.5 %, Sp = 66.3 %), septum pellucidum displacement ?1 mm (Se = 71.6 %, Sp = 71.2 %) and ANLR 2.92 (Se = 86.5 %, Sp = 36.5 %) were independently associ¬ated with an increased risk of the unfavourable FO of the acute period of SSICH by 4.9 (2.9–8.3) (P 0.0001), 2.9 (2.6–3.3) (P 0.0001) and 2.4 (2.1–2.7) (P 0.0001) times respectively. Conclusions. Multivariate models for lethal outcome prognosis (AUC Экз-ры: