Вид документа : Статья из журнала Шифр издания : Автор(ы) : Khranovskaya N. M., Inomistova M. V., Klymnyuk G. I. Заглавие : Role of miRNAs in neuroblastoma pathogenesis (review) Параллельн. заглавия :Роль мікроРНК в патогенезі нейробластоми (огляд літератури) Место публикации : Клініч. онкологія. - К., 2013. - N 1. - С. 145-148 (Шифр КУ41/2013/1) Предметные рубрики: НЕЙРОБЛАСТОМА-- NEUROBLASTOMA РНК-- RNA Аннотация: Neuroblastoma is a sympathetic nervous system malignant tumor which is derived from the neural crest cells and constitutes 7–11% of the total number of childhood malignant tumors. Despite the comparatively low level of the disease, about 15% of pediatric cancer deaths are associated with neuroblastoma. As genetically complex cancer, neuroblastoma displays significant genetic heterogeneity. That is why strikingly different outcomes are observed across tumor subtypes - from spontaneous regression without therapy to rapid progression and death due to disease. Genomic amplification of the MYCN oncogene is used to predict the neuroblastoma disease outcome for over 30 years, however, recent methodological advances including microRNA and mRNA profiling, comparative genomic hybridi¬zation and whole genome sequencing allow to conduct a deeper neuroblastoma genome analysis leading to the identification of new prognostic markers and better patient stratification. In this review, we describe the major epigenetic factors responsible for these diverse clinical neuroblastoma phenotypes. Доп.точки доступа: Inomistova, M. V.; Klymnyuk, G. I.