Вид документа : Статья из журнала Шифр издания : Автор(ы) : Ziablitsev S.V., Korobova А.V., Petrenko О.V., Serduk V. N., Mogilevsky S. U. Заглавие : Role of matrix metalloproteinase 9 and its tissue inhibitor 1 in development and prognosis of diabetic retinopathy Место публикации : Фізіологічний журнал. - К., 2016. - Том 62, N 5. - С. 37-44 (Шифр ФУ6/2016/62/5) MeSH-главная: ДИАБЕТИЧЕСКИЕ НЕФРОПАТИИ -- DIABETIC NEPHROPATHIES ИММУНОФЕРМЕНТНЫЕ МЕТОДЫ -- IMMUNOENZYME TECHNIQUES ПРОТЕОЛИЗ -- PROTEOLYSIS МАТРИКСА МЕТАЛЛОПРОТЕИНАЗА 9 -- MATRIX METALLOPROTEINASE 9 ТКАНЕВОЙ ИНГИБИТОР МЕТАЛЛОПРОТЕИНАЗЫ-1 -- TISSUE INHIBITOR OF METALLOPROTEINASE-1 ВОДЯНИСТАЯ ВЛАГА -- AQUEOUS HUMOR ПРОГНОЗ -- PROGNOSIS Аннотация: The article presents the results of investigation of violations in the proteolysis system inpatients with type 2 diabetes and diabetic retinopathy (DR). We studied the levels of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) in the blood and in the intraocular fluid of patients with type 2 diabetes depending upon the stage of DR. We have established that the level of MMP-9 and TIMP-1 in the blood and in the intraocular fluid increased in patients with type 2 diabetes without signs of DR and with any stage of DR compared to the levels of these parameters in patients without diabetes. Increasing the levels of MMP-9 and TIMP-1 took place with increasing of DR severity and reached its maximum levels at the proliferative stage of DR. It was found that the levels of MMP-9 in the intraocular fluid and type 2 diabetes duration affected the probability of developing diabetic macular edema. At the level of MMP-9?105 ng/ml and 2 diabetes duration ? 10 years, the probability of developing macular edema was 100%. As a result of the construction of predictive models it was found that the level of MMP-9 in the intraocular fluid, stage of DR at the beginning of observation and type 2 diabetes duration had influence on the probability of the development of proliferative DR over 4 years of follow-up. If the level of MMP-9 ?100 ng/ml, type 2 diabetes duration ? 10 years and absence of DR at the beginning of observation were observed the probability of developing proliferative DR would compose 85.9%. Доп.точки доступа: Ziablitsev, S.V.; Korobova, А.V.; Petrenko, О.V.; Serduk, V. N.; Mogilevsky, S. U.