Вид документа : Статья из журнала Шифр издания : Автор(ы) : Krynytska I.Ya., Marushchak M.I., Klishch I.M. Заглавие : Molecular mechanisms of hepatopulmonary syndrome Место публикации : Фізіологічний журнал. - К., 2017. - Том 63, N 3. - С. 90-102 (Шифр ФУ6/2017/63/3) MeSH-главная: ПЕЧЕНИ БОЛЕЗНИ -- LIVER DISEASES ГЕПАТОПУЛЬМОНАЛЬНЫЙ СИНДРОМ -- HEPATOPULMONARY SYNDROME МОДЕЛИ МОЛЕКУЛЯРНЫЕ -- MODELS, MOLECULAR ОБЗОР -- REVIEW Аннотация: Hepatopulmonary syndrome (HPS) is a severe complication seen in advance liver disease. Its prevalence among cirrhotic patients varies from 4 to 47 percent. HPS exact pathogenesis remains unknown. In this review we summarized existing knowledge on the possible mechanisms and causes of the HPS. Pulmonary microvascular dilation and angiogenesis are two central pathogenic features that drive abnormal pulmonary gas exchange in experimental HPS, and thus might underlie HPS in humans. Despite these insights into the pathogenesis of experimental HPS, there is no established medical therapy, and liver transplantation remains the main treatment. Доп.точки доступа: Krynytska, I.Ya.; Marushchak, M.I.; Klishch, I.M.