Вид документа : Статья из журнала Шифр издания : Автор(ы) : Kochmar M. Yu., Golosh Ju. V., Hetsko O. I. Заглавие : Effect of monosodium glutamate on organs of the digestive system in humans and rats Место публикации : Вісн. пробл. біол. і медицини. - Полтава, 2022. - № 3. - С. 58-63 (Шифр ВУ12/2022/3) MeSH-главная: НАТРИЯ ГЛУТАМАТ -- SODIUM GLUTAMATE ЖЕЛУДОЧНО-КИШЕЧНЫЙ ТРАКТ -- GASTROINTESTINAL TRACT ПИЩЕВАРИТЕЛЬНАЯ СИСТЕМА -- DIGESTIVE SYSTEM Аннотация: Sodium glutamate is widely used in the manufacture of food and drugs. Greatest The share in the consumption of monosodium glutamate falls on the Asian population. A number of authors point to a positive Effects of the use of monosodium glutamate in medicine. Most studies of the effects of MSG on the body have been conducted on white male rats. There are different views on the extrapolation of experimental results from laboratory animals on humans. Common effects of the effects of monosodium glutamate on humans and animals mainly described as metabolic disorders. Even a slight increase in the daily dose of monosodium glutamate has been shown to significantly increase the risk of metabolic syndrome and overweight in certain populations, regardless of diet and level of physical activity. In experimental animals, obesity is observed, an increase in body weight, development of insulin resistance, secretion of somatostatin and insulin. In particular, it was reported that The use of monosodium glutamate changes the biochemical parameters of blood serum. Increased serum glucose, insulin, total cholesterol,and triglycerides, which are most commonly associated with liver damage and kidneys, including renal tubules. In this case, glucose is detected in the urine. Due to the local inflammatory reaction in the liver tissue, lymphocytic infiltration, signs of edema, impaired microcirculation, progressive development of tissue hypoxia, fibrosis and lipolysis occur. Apoptosis was also recorded in hepatocytes, nuclear pycnose, nuclear membrane lysis, cytoplasmic vacuolization, mitochondrial edema, endoplasmic reticulum and sinusoidal telangiectasia, disassembly of collagen fibers in the extracellular space. Into tissues increased the level of proteins. It has been shown that prolonged use of monosodium glutamate directly increases blood pressure in humans and animals, and also caused arrhythmia. Доп.точки доступа: Golosh, Ju. V.; Hetsko, O. I.