Experimental therapy of graft-versus-host disease by mesenchymal stromal cells grown on oxide nanocoatings [Text] / A. N. Goltsev [et al.] // Фізіологічний журнал. - 2016. - Том 62, N 5. - P3-11 MeSH-главная: МОЗГ ГОЛОВНОЙ -- BRAIN (цитология) СТВОЛОВЫЕ КЛЕТКИ ПОЛИПОТЕНТНЫЕ -- MULTIPOTENT STEM CELLS (трансплантация) СТРОМАЛЬНЫЕ КЛЕТКИ МЕЗЕНХИМНЫЕ -- MESENCHYMAL STROMAL CELLS ТРАНСПЛАНТАТ ПРОТИВ ХОЗЯИНА, БОЛЕЗНЬ -- GRAFT VS HOST DISEASE (терапия) IN VITRO МЕТОДЫ -- IN VITRO TECHNIQUES НАНОЧАСТИЦЫ -- NANOPARTICLES (терапевтическое применение) ЭКСПЕРИМЕНТЫ НА ЖИВОТНЫХ -- ANIMAL EXPERIMENTATION Аннотация: Immune aggression to transplanted allogeneic bone marrow, i.e. the graft-versus-host disease (GVHD), could be decreased by the suppression of effector and/or activation of T- regulatory cells (Treg). This task could be solved by co-transplantaiton of allogeneic bone marrow and mesenchymal stromal cells (MSCs). This study demonstrated the elevated immune modulating activity of MSCs by their culturing in vitro on Al203 oxide nanocoatings. Introduction of the cells to the animals with GVHD resulted in an increased content of Treg in the spleen of bone marrow recipients, reduced severity of the pathology, and higher survival of animals. The findings could be the basis for developing the new approaches to optimize the GVHD treatment methods involving the oxide nanocoating cultured MSCs. Доп.точки доступа: Goltsev, A.N.; Rassokha, I.V.; Dubrava, T.G.; Ostankova, L. V.; Ostankov, M. V.; Safonov, V. I.; Zykova, A. V. Экз-ры: