Melatonin, placental growth factor and placental hormones at placental insufficiency [] / A. Berbets [et al.] // Клітинна та органна трансплантологія. - 2019. - Том 7, N 2. - С. 103-107. - Bibliogr. at the end of the art. MeSH-главная: ПЛАЦЕНТАРНАЯ НЕДОСТАТОЧНОСТЬ -- PLACENTAL INSUFFICIENCY (патофизиология, этиология) МЕЛАТОНИН -- MELATONIN (анализ, дефицит, диагностическое применение, физиология) ПЛОДА РАЗВИТИЯ ЗАДЕРЖКА -- FETAL GROWTH RETARDATION (патофизиология, этиология) ШИШКОВИДНАЯ ЖЕЛЕЗА -- PINEAL GLAND (анатомия и гистология, ультраструктура, физиология) ПРОГЕСТЕРОН -- PROGESTERONE (анализ, дефицит) ПЛАЦЕНТАРНЫЙ ЛАКТОГЕН -- PLACENTAL LACTOGEN (анализ, дефицит, физиология) Аннотация: A pineal gland attracts much attention of scientists lately, because it secrets melatonin, which is a very important hormone. Melatonin plays a significant role in the development of pregnancy: it enhances implantation, decreases oxidative stress etc. At the same time, the links between the pineal gland and the placenta, as a part of endocrine system of a mother, are still not well described. Objective of the study. To investigate the pathogenic links between secretion of melatonin, placental growth factor and reproductive hormones in pregnant women with placental insufficiency, manifested as intrauterine fetal growth restriction. Material and methods. 35 pregnant women aged 18-36 with placental insufficiency (PI) were examined (study group). The placental insufficiency manifested as the intrauterine fetal growth restriction (IUGR) in the 3rd pregnancy trimester. The control group consisted of 20 women with uncomplicated pregnancy at the same term. The blood concentrations of melatonin and placental growth factor (PlGF) were studied, as well as the blood concentrations of certain placental hormones: progesterone, placental lactogen and unconjugated estriol. Results. The concentration of melatonin was found to decrease significantly, if pregnancy was complicated by intrauterine fetal growth retardation (study group – 129.90 ± 17.65 pg/ml, control group – 231.25 ± 21.56 pg/ml, p 0.01), as well as concentration of PlGF (study group – 130,78 ± 15,80 pg/ml, control group – 230.0 ± 29.97 pg/ml, p 0.01). A significant difference of progesterone concentrations between the groups was found (study group: 15.36 ± 2.78 ng/ml, control group: 30.43 ± 2.66 ng/ml, p 0.01), as well as for placental lactogen (study group: 6.31 ± 2.08 mg/l, control group: 7.76 ± 1.93 mg/l, p 0.05). No significant difference between the concentrations of unconjugated estriol was found. A close correlation between melatonin and progesterone in the control group was found (r Доп.точки доступа: Berbets, A.; Konkov, D.; Bulavenko, О.; Taran, O.; Bakun, O. Экз-ры: