Comparative study of antitumor effect Fe2O3 and Fe3O4 nanoparticles in nanocomplex with doxorubicin during electromagnetic irradiation and modification of human hepatocellular carcinoma cells (HepG2) with interferon-alpha [] = Порівняльне дослідження протипухлинного впливу наночастинок Fe2O3 з Fe3O4 у нанокомплексі з доксорубіцином при електромагнітному опроміненні за умов модифікації клітин гепатоклітинної карциноми людини (HepG2) інтерфероном альфа / V. Е. Orel [et al.] // Клініч. онкологія = Клиническая онкология. - 2013. - N 1. - С. 140-144 Рубрики: КАРЦИНОМА--CARCINOMA    НАНОЧАСТИЦЫ--NANOPARTICLES    ЛУЧЕВАЯ ТЕРАПИЯ--RADIOTHERAPY    ИНТЕРФЕРОН-АЛЬФА--INTERFERON-ALPHA Аннотация: Conducted experimental studies in human hepatocellular carcinoma cell line HepG2 showed that highest cytotoxic effect was observed when nanocomplex (NC) which consisted of Fe2O3 nanoparticles (NP) with doxorubicin (DR) was used, as well as Fe3O4 NP or a mixture Fe2O3+Fe3O4 with DR after prolonged exposure to interferon-alpha (IFN). The number of apoptotic cells increased when NC which consisted of Fe3O4 and/or Fe2O3 NP with DR was used after electromagnetic irradiation (EI) and prolonged exposure to IFN compared to the experiments when EI was not used. The number of topoisomerase II alpha-positive cells decreased when NC with Fe3O4 NP and DR was used after EI and long-term exposure to IFN compared with experiments when Fe2O3 NP and DR were used. Доп.точки доступа: Orel, V. Е.; Bezdyenyezhnih, N. О.; Nikolov, М. О.; Romanov, A. V.; Khranovskaya, N. M.; Skachkova, O. V.; Kudryavets, Yu. I.; Schepotin, I. B. Экз-ры: