Traverse, G. The Effect of Physical Activity on the Secretory Function of Muscles and Bone Tissue in Humans [Text] / G. Traverse, V. Horoshko, S. Danylchenko // Український журнал медицини, біології та спорту. - 2023. - Т. 8, № 1. - P50-55. - Bibliogr.: p. 53-54 MeSH-главная: МЫШЦА СКЕЛЕТНАЯ -- MUSCLE, SKELETAL (иннервация, кровоснабжение, рост и развитие, секреция, химия) АДЕНИЛАТКИНАЗА -- ADENYLATE KINASE (антагонисты и ингибиторы, иммунология, стандарты, ультраструктура, химический синтез) ПЕРОКСИСОМЫ -- PEROXISOMES (действие лекарственных препаратов, метаболизм, патология, секреция, ультрасонография) КОСТИ ПЛОТНОСТЬ -- BONE DENSITY (воздействие облучения, генетика, действие лекарственных препаратов, иммунология, физиология) ФИЗИОЛОГИЧЕСКИЕ ПРОЦЕССЫ -- PHYSIOLOGICAL PROCESSES (воздействие облучения, генетика, действие лекарственных препаратов, иммунология, физиология) ПРЕСТАРЕЛЫЕ ОСЛАБЛЕННЫЕ -- FRAIL ELDERLY (психология, статистика) Кл.слова (ненормированные): skeletal muscles, myokines, protein irisin, bone density, environmental homeostasis, Аннотация: The purpose of the study was to summarize new literature data on the effect of physical activity on the secretory function of skeletal muscles and their relationship with organs. Materials and methods. Analytical methods were used in the study. The search for scientific information was carried out in databases of search systems. Results. Muscles secrete proteins called myokines, which are involved in a variety of processes by interacting with tissues. Current research has shown that exercise, by stimulating the skeletal muscle system in vivo, leads to the release of myokines and causes several effects that explain the positive effect of exercise in the treatment of several diseases of the musculoskeletal system. Skeletal muscles synthesize and secrete a wide range of myokines that contribute to various functions in organs, including the brain. Recent publications have focused much attention on one such myokine, the recently discovered protein irisin, which is secreted into the bloodstream from skeletal muscle during exercise from the membrane-bound precursor fibronectin type III. Irisin promotes metabolic processes such as glucose homeostasis and the darkening of white adipose tissue. Irisin also crosses the bloodbrain barrier and initiates a neuroprotective genetic program in the hippocampus, which culminates in increased expression of brain-derived neurotrophic factors. Most studies report that irisin concentration is closely related to health status. For example, irisin levels are significantly lower in patients with obesity, osteoporosis/fracture, muscular atrophy, Alzheimer’s disease, and cardiovascular disease. Доп.точки доступа: Horoshko, V.; Danylchenko, S. Экз-ры: |